This black-and-white 1958 Bufferin ad shows a dark-haired woman in a pearl necklace and bracelet pressing her fingers to her temple with her eyes squeezed shut, surrounded by a stack of dirty dishes in a kitchen. A cutaway drawing of a human figure shows the path through the stomach, and a Bufferin package sits at the lower right.

• Headline claims Bufferin relieves pain twice as fast
• Subhead credits Di-Alminate for making the difference
• Numbered copy compares aspirin with and without antacid
• Good Housekeeping guarantee seal beside the package
• A telling pick for medicine, household, and 1950s ad collectors
• Measures approximately: 8" x 11"